Lactic dehydrogenase was quantitated and its isozyme pattern studied in the leukocytes of 10 patients with chronic lymphocytic leukemia. There was a wide range of LDH activity, although all isozyme patterns by starch-gel electrophoresis showed greatest activity in the No. III isozyme band. Comparison of the rate of migration of the leukemic leukocyte LDH with LDH from normal leukocytes and erythrocytes showed no difference in migration rate, suggesting that the LDH of chronic lymphocytic leukemic leukocytes does not differ in electrical charge from LDH of normal leukocytes.

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