Several orally administered beef spleen preparations were evaluated for their effect on platelet and leukocyte counts of rats. In some studies, cow spleen exerted a definite though variable count lowering activity. Further studies yielded less dramatic or negative results. Pooled beef spleen, whole or crudely fractionated, had no demonstrable effect on the blood counts.

Other variables, including temperature, feeding methods, seasonal factors, and animal housing did not appear significant.

No consistent, predictable effect of beef spleen feedings could be demonstrated under the various conditions tested.

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