The kinetics, serologic and immunochemical characteristics of cold agglutinins (CA) produced in rabbits by the intravenous injection of HKLM serotype 4b have been studied.

The cold agglutinin was a γM-immunoglobulin. It agglutinated autologous, allogeneic and human erythrocytes at 4 C. In the presence of complement the CA was hemolytic in vitro and in vivo. The relevance of these observations to concepts of autoimmunity is discussed.

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