Immune sera produced against adult human, fetal, canine and rabbit hemoglobin solutions were found to agglutinate specifically the papain-treated red cells of the respective donors to a high titer. Intact red cells were also specifically agglutinated by the same antibody-containing sera in the presence of dextran, suggesting that the antibodies produced are incomplete ones.

A marked shortening of the life span of rabbit erythrocytes followed the intravenous injection of anti-rabbit hemoglobin serum into normal rabbits.

The possible implications of the above findings in human pathology are discussed.

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