1. A Negro family is reported in which 3 sisters were found to have congenital hemolytic icterus.
2. All members of the family observed showed strong Negroid characteristics. There was nothing to suggest an admixture of white blood.
3. The literature was reviewed. Including the 3 reported in this paper, 8 cases have been reported. The disease may be more common in the female as the reported cases show 7 females to 1 male.
4. Congenital hemolytic icterus, on rare occasions, occurs in the Negro race and recognizing it as such is helpful since splenectomy is of distinct value.