We have discussed three types or stages of blood changes in hookworm disease. Attention is directed to a severe irreversible aplastic anemia which occurs not infrequently in hookworm disease. The pathogenesis is obscure, but we believe that it is due to bone marrow exhaustion following continuous blood loss in the presence of various factors, including dietary deficiency.

The symptomatology, hematologic and bone marrow findings are described.

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