A method for studying the leukocyte alkaline phosphatase activity in patients with acute leukemia is described. The technic overcomes the problem of obtaining sufficient numbers of mature granulocytes for study in such patients. Seven of 11 patients with acute monocytic leukemia were shown to have elevated levels of alkaline phosphatase activity. It is suggested that this method may be of assistance in classifying the stem cell forms of leukemia.

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