GEORGE B. JERZY GLASS, DUK HO LEE, WILLIAM W. HARDY; Hydroxocobalamin. II. Absorption from the Site of Injection and Uptake by the Liver and Calf Muscle in Man. Blood 1961; 18 (5): 522–526. doi: https://doi.org/10.1182/blood.V18.5.522.522
Labeled hydroxocobalamin, administered intramuscularly in man, is absorbed more slowly from the site of injection and deposited in the liver and calf muscle to a degree equal to or higher than that of cyanocobalamin at an equivalent dose. These findings, together with those reported in Part I of this paper, suggest the applicability of hydroxocobalamin as a long-acting vitamin B12 in man. These conclusions, however, require the support to be obtained from long-range observations on patients with vitamin B12 depletion.