ROBERT A. KYLE, ROBERT S. SCHWARTZ, HERMAN L. OLINER, WILLIAM DAMESHEK; A Syndrome Resembling Adrenal Cortical Insufficiency Associated with Long Term Busulfan (Myleran) Therapy. Blood 1961; 18 (5): 497–510. doi: https://doi.org/10.1182/blood.V18.5.497.497
Four patients who developed a clinical syndrome characterized by hyperpigmentation of the skin, weakness, fatigue, weight loss, anorexia and nausea while on long-term treatment with busulfan were described. The etiology of the disorder, although clearly related to the busulfan therapy, is obscure, but may be related to "dethiolation".