1. Seventy-five cases of S-C hemoglobin disease were studied, ranging in age from 14 months to 66 years.
2. Pain in the splenic area was the most common presenting complaint, splenomegaly being readily demonstrable in about two-thirds of the cases.
3. Hematuria, epistaxes and concomitant infections occurred with sufficient frequency to suggest a relationship to the underlying S-C disease.
4. Pregancy was tolerated fairly well.
5. Although a number of clinical and hematologic features are suggestive of S-C disease, the diagnosis must still be based on electrophoretic studies of the hemoglobin.