The morphology of buffy coat from cord blood of normal human newborns was investigated and the results were compared with our previous observations in adults.

Direct smears from cord blood were examined. Increased alkaline phosphatase activity was found in the granulocytes.

Hotchkiss PAS staining was positive in up to 2 per cent of normoblasts.

The examination of buffy coat revealed 28 normoblasts per 1000 granulocytes. Nuclei and/or nuclear fragments of megakaryocytes were encountered 27 times more frequently in newborns than in adults. Myelocytes and/or metamyelocytes were seen 16 times more often in newborns. Atypical mononuclear cells were found in all the subjects examined. Giant metamyelocytes and staff cells were encountered in 10 cases.

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