The graft vs. host reaction (runt disease) was studied in LAF1, BDF1, and BAF1, mice. The disease was induced by the injection of parental splenic tissue into adult recipients.

The F1 hybrid recipients developed weight loss, hair changes, dermatitis, hypothermia and splenomegaly. The laboratory features included hemolytic anemia with a positive antiglobulin test, leukopenia, thrombocytopenia and abnormalities of their plasma electrophoretic patterns.

Certain similarities between runt disease and autoimmune diseases of man were suggested, and their significance was discussed.

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