Dog arterial and venous plasma and lymph were fractionated by Cohn method 10 and the fractions tested for inhibitory activity when added to normal arterial blood in the dog hind leg preparation adapted for studies on hemostasis.

Cohn fraction IV from arterial or venous plasma and from lymph was the only fraction, at low concentrations, able to inhibit the hemostatic ability of normal arterial plasma.

Some facts suggest that alpha-lipoproteins are the plasma constituent of fraction IV with inhibitory effect on normal arterial blood. Biochemical changes in blood plasma seem more important or more directly connected with the mechanism of normal hemostasis control than the participation of blood cellular elements.

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