A 26 year old American housewife of Sardinian extraction with chronic hypochromic anemia was found to have a hemoglobin component identical to hemoglobin H. The A2 hemoglobin fraction was decreased. Relatives were found to exhibit the hematologic features of thalassemia trait. In this pedigree, in contrast to the usual finding in the "thalassemia trait," the A2 values were not increased. The same observation had been made in the only other comparable report.

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