A simple method for measuring the control of blood loss in thrombocytopenic rats and mice is described.

The administration of lyophilized platelets, brain phospholipid extract and soya bean extract failed to correct the blood loss in the thrombocytopenic animal.

The results obtained with this method have failed to support the effectiveness of "platelet substitutes" in in vivo systems and reaffirm the requisites of viability and recirculation for platelet transfusions.

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