A new agglutination phenomenon in the ABO group system is described. This phenomenon consists of the development of agglutinates by interaction between a single specifically sensitized cell and other unsensitized, nonantigenic cells. Aggregates of cells formed in this way are tentatively described as "anomalous mixed agglutinates."

Some of the properties of anomalous mixed agglutinates have been investigated, and the impact of these properties on the current theories of agglutination is briefly discussed.

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