There are errors in the data presented in Tables 2 and 5. As a result, incorrect data values are also quoted in several places within the text of the manuscript.

In the last row of Table 2 on page 2041, “0.7 (0.0-6.0)” should be “6.5 (0-60).”

In lines 5 and 6 of the first full paragraph on page 2042, “median and 2-sided 95% CIs for the mean (standard deviation)” should read “mean (standard deviation) and 2-sided 95% CIs for the mean.”

Also, the data presented in Table 5 (page 2042) and Figure 3 (page 2043) are incorrect. The corrected Table 5 and Figure 3 are shown below. As a result of these errors, the mean von Willebrand factor (VWF):ristocetin cofactor activity (RCo) terminal half-life listed in the abstract on page 2038, “Results” on page 2043, and “Discussion” on page 2044 should be 22.6 hours (95% confidence interval [CI], 19.5-25.7) for recombinant VWF (rVWF) alone and 22.5 hours (95% CI, 17.4-27.6) for rVWF administered with recombinant factor VIII (rFVIII).

Table 5.

Pharmacokinetic data for rVWF and rVWF:rFVIII

Mean (SD)
95% CI of mean
50 IU VWF:RCo/kg80 IU rVWF VWF:RCo/kg
PK1 (N = 15)PK2 (N = 13)Type 3 VWD only
rVWF:rFVIII (N = 16)rVWF (N = 14)PK1 (N = 11)PK2 (N = 10)
T1/2 (h) 22.5 (9.6) 22.6 (5.3) 19.1 (4.3) 21.0 (5.7) 19.1 (4.9) 20.5 (4.7) 
 17.4-27.6 19.5-25.7 16.7-21.5 17.6-24.5 15.8-22.4 17.1-23.9 
AUC0-∞/dose ([h*U/dL]/[U VWF:RCo/kg]) 41.7 (14.8) 42.1 (8.3) 36.8 (9.0) 38.2 (9.1) 38.4 (7.1) 38.2 (10.3) 
33.8-49.6 37.3-46.9 31.8-41.8 32.8-43.7 33.6-43.2 30.8-45.5 
Cmax (U/dL) 95.9 (27.6) 93.6 (21.0) 155.7 (31.6) 150.2 (34.5) 161.8 (32.3) 152.5 (30.6) 
 81.2-110.6 81.5-105.8 138.2-173.2 129.4-171.1 140.1-183.5 130.6-174.4 
IR at Cmax ([U/dL]/[U VWF:RCo/kg]) 1.9 (0.5) 1.9 (0.4) 2.0 (0.4) 1.9 (0.4) 2.0 (0.4) 1.9 (0.4) 
1.6-2.2 1.6-2.1 1.7-2.2 1.6-2.1 1.8-2.3 1.6-2.2 
CL (dL/kg/h) 0.027 (0.010) 0.025 (0.005) 0.029 (0.009) 0.028 (0.007) 0.027 (0.007) 0.028 (0.008) 
 0.022-0.032 0.022-0.028 0.024-0.034 0.023-0.032 0.023-0.032 0.022-0.034 
Vss (dL/kg) 0.79 (0.27) 0.77 (0.15) 0.75 (0.22) 0.79 (0.26) 0.71 (0.21) 0.76 (0.17) 
 0.64-0.93 0.68-0.86 0.62-0.87 0.63-0.95 0.56-0.85 0.64-0.88 
MRT (h) 32.2 (14.5) 31.9 (7.5) 26.1 (6.0) 29.3 (9.8) 26.3 (6.9) 28.2 (7.6) 
 24.4-39.9 27.6-36.3 22.8-29.5 23.4-35.3 21.7-30.9 22.7-33.6 
Mean (SD)
95% CI of mean
50 IU VWF:RCo/kg80 IU rVWF VWF:RCo/kg
PK1 (N = 15)PK2 (N = 13)Type 3 VWD only
rVWF:rFVIII (N = 16)rVWF (N = 14)PK1 (N = 11)PK2 (N = 10)
T1/2 (h) 22.5 (9.6) 22.6 (5.3) 19.1 (4.3) 21.0 (5.7) 19.1 (4.9) 20.5 (4.7) 
 17.4-27.6 19.5-25.7 16.7-21.5 17.6-24.5 15.8-22.4 17.1-23.9 
AUC0-∞/dose ([h*U/dL]/[U VWF:RCo/kg]) 41.7 (14.8) 42.1 (8.3) 36.8 (9.0) 38.2 (9.1) 38.4 (7.1) 38.2 (10.3) 
33.8-49.6 37.3-46.9 31.8-41.8 32.8-43.7 33.6-43.2 30.8-45.5 
Cmax (U/dL) 95.9 (27.6) 93.6 (21.0) 155.7 (31.6) 150.2 (34.5) 161.8 (32.3) 152.5 (30.6) 
 81.2-110.6 81.5-105.8 138.2-173.2 129.4-171.1 140.1-183.5 130.6-174.4 
IR at Cmax ([U/dL]/[U VWF:RCo/kg]) 1.9 (0.5) 1.9 (0.4) 2.0 (0.4) 1.9 (0.4) 2.0 (0.4) 1.9 (0.4) 
1.6-2.2 1.6-2.1 1.7-2.2 1.6-2.1 1.8-2.3 1.6-2.2 
CL (dL/kg/h) 0.027 (0.010) 0.025 (0.005) 0.029 (0.009) 0.028 (0.007) 0.027 (0.007) 0.028 (0.008) 
 0.022-0.032 0.022-0.028 0.024-0.034 0.023-0.032 0.023-0.032 0.022-0.034 
Vss (dL/kg) 0.79 (0.27) 0.77 (0.15) 0.75 (0.22) 0.79 (0.26) 0.71 (0.21) 0.76 (0.17) 
 0.64-0.93 0.68-0.86 0.62-0.87 0.63-0.95 0.56-0.85 0.64-0.88 
MRT (h) 32.2 (14.5) 31.9 (7.5) 26.1 (6.0) 29.3 (9.8) 26.3 (6.9) 28.2 (7.6) 
 24.4-39.9 27.6-36.3 22.8-29.5 23.4-35.3 21.7-30.9 22.7-33.6 

CL, clearance; Cmax, maximum concentration; MRT, mean residence time; PK1, initial PK assessment; PK2, PK assessment 6 mo after initial PK; SD, standard deviation.

Figure 3.

VWF:RCo of rVWF. Median, IQR, and range of VWF:RCo after infusion of 50 IU VWF:RCo/kg rVWF alone and together with rFVIII.

Figure 3.

VWF:RCo of rVWF. Median, IQR, and range of VWF:RCo after infusion of 50 IU VWF:RCo/kg rVWF alone and together with rFVIII.

Under “PK” on page 2043, the ratio between the geometric mean AUC0-∞/dose of VWF:RCo for rVWF alone vs rVWF administered with rFVIII should be “1.02; 90% CI, 0.93-1.11.” In the same section, as well as in “Discussion” on page 2044, the incremental recovery (IR) should be 1.9 U/dL VWF:RCo/kg for rVWF with or without rFVIII.

These errors have been corrected in the online version of the article.