The principle of the "mixed agglutination" reaction has been applied to the development of a technic for the detection of minor populations of erythrocytes in mixtures in which the minor component is identifiable by means of one or another of the blood group iso-antigens. The method lends itself to the quantification of a minor population and provides a degree of sensitivity which compares very favorably with that which can be achieved through the use of radioactive tracers.

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