The clinical, hematologic, and pathologic findings in 26 cases of leukemic reticuloendotheliosis are presented.

A histopathologic correlation of the various forms of leukemia is suggested. Clinically the disease may follow an acute, subacute, or chronic course There is no idiopathic clinical sign or symptom, but the hematologic picture is pathognomonic and is characterized by the presence of reticulum cells in the peripheral blood and bone marrow. These cells are also present in the organs where the reticuloendothelial system predominates: spleen, liver, and lymph nodes.

The study of these cases supports the concept that leukemic reticuloendotheliosis is an independent hematologic and pathologic entity.

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