A mucin fraction with high content of A and H blood group substances was obtained from hog gastric mucosa. This fraction administered per os together with vitamin B12 in rats made anemic by phenylhydrazine injection shows a significant effect on the hematologic response in comparison with the animal treated with vitamin B12 alone.

The same fraction administered per os in cortisone-treated rats has also a significant nitrogen sparing action.

The possible mechanisms and relationships of the observed biologic effects are briefly discussed.

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