EUGENE GOLDWASSER, LEON O. JACOBSON, WALTER FRIED, LOUIS F. PLZAK; Studies on Erythropoiesis : V. The Effect of Cobalt on the Production of Erythropoietin. Blood 1958; 13 (1): 55–60. doi: https://doi.org/10.1182/blood.V22.214.171.124
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It has been shown that plasma from animals that have been injected with cobaltous chloride rapidly develops a high titer of erythropoietin.
The gross properities of the active material appear to be the same from cobalt-treated as from phenylhydrazine-treated animals.
Other metal ions and a complex ion have been studied as stimulants for erythropoietin formation; none was as effective as cobaltous ion with the exception of cobaltic hexamine.
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