It has been shown that plasma from animals that have been injected with cobaltous chloride rapidly develops a high titer of erythropoietin.

The gross properities of the active material appear to be the same from cobalt-treated as from phenylhydrazine-treated animals.

Other metal ions and a complex ion have been studied as stimulants for erythropoietin formation; none was as effective as cobaltous ion with the exception of cobaltic hexamine.

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