Texture analysis is a novel approach, which analyses the distribution of pixel on computed tomography (CT) within a region of interest. CT-based texture analysis (CTTA) can be applied to images that are acquired in routine clinical practice and provide prognostic information in patients with non-small cell lung cancer or colorectal adenocarcinoma. We aimed to assess whether CTTA could predict the outcome in patients with Hodgkin lymphoma (HL).


All consecutive patients who received chemotherapy for HL at our center between 2007 and 2015 were considered for analysis. Patients without available CT at baseline and/or at interim analysis in the picture archiving and communication system (PACS) of our center were excluded. Overall, 56 patients (15 early and 41 advanced stages) were included in this retrospective study. Median age was 34.6 years (range, 17-78) and 64% patients were male. First line chemotherapy were ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine; n=42), escalated-dose BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone; n=12) and ABVD without bleomycin (n=2). Median follow-up was 37.6 months (5-103).

CTTA was performed using TexRAD® software on single-slices on baseline CT and interim CT (after 2 or 4 cycles of chemotherapy). CTTA parameters and their changes were compared with disease response, relapse and disease-free survival (DFS). Receiver operating characteristic (ROC) curve analyses were performed to identify the strongest parameter and the optimal cutoff value for predicting relapse.


On baseline CT, the strongest parameter predictive of relapse was MPP (mean positive pixels). With a spacial scale filter (ssf) of 2, CTTA < 27.5 (cut off value) were defined as positive. Cumulative incidence of relapse (IR) and 5-year DFS were 36.4% and 54.5% in patients with positive baseline CTTA compared to 11.1% and 82.2% in patients with negative baseline CTTA (p=0.053 and p=0.077, respectively). Baseline CTTA significantly predicted relapse and DFS in early stages patients (p=0.015 and p=0.015, respectively) and in advanced stages patients treated with ABVD (p=0.042 and p=0.025, respectively). However, outcomes were not significantly different according to baseline CTTA in patients treated with escalated-dose BEACOPP. Indeed, DFS tented to be improved with escalated-dose BEACOPP (87.5%) compared to ABVD (67.5%).

On interim CT, the strongest parameter predictive of relapse was the entropy (ssf=4). CTTA > 5 (cut off value) were defined as positive. Patients with positive interim CTTA had a cumulative IR and a 5-year DFS of 50% and 37.5% compared to 10.4% and 83.3% in patients with negative baseline CTTA (p=0.002 and p=0.004, respectively). Interim CTTA could significantly predict the outcome both in early and advanced stages patients. Interestingly, only one patient treated with BEACOPP had a positive interim CTTA. Finally, positive interim CTTA was significantly associated with DFS in patients with negative (p=0.015) or positive (p=0.049) interim 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET).


Texture analysis on baseline and interim CT can provide prognostic information in patients with HL. It may be used at diagnosis to identify high-risk patients and guide the initial treatment choice. At interim analysis, the combination of CTTA and PET may help clinicians to better adapt therapy.


Garderet:Takeda: Consultancy; Amgen: Consultancy; Novartis: Consultancy; Bristol-Myers Squibb: Consultancy.

Author notes


Asterisk with author names denotes non-ASH members.