Forty patients with Hodgkin’s disease were treated with CB 1348 or R-48 or both. These drugs are useful and easy to administer. They have a therapeutic effect upon subjective symptoms and enlarged lymph nodes. The average remission lasts two months, shorter in some cases and longer in other cases. Toxicity is minimal. Hematologic depression occurs late as a rule and is reversible upon discontinuance of the drugs. Both drugs appeared to produce the same effect at about the same rate, and the effect lasted for about the same length of time. R-48 proved effective in some instances where CB 1348 had not been so, and CB 1348 sometimes induced a remission when T. E. M. had failed. In some cases radiation therapy caused recession of nodes when both drugs had been ineffective.