Hypoprothrombinemia was encountered in 105 patients including cases of vitamin K deficiency, liver disease, newborns, Dicumarol-type drug therapy and a few miscellaneous disorders. The findings stress the association of acquired hypoprothrombinemia with deficiencies proconvertin and PTC and suggest that these three proteins are formed in the liver and that vitamin K is essential to their production.

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© 1957 by American Society of Hematology, Inc.
1957

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