Lysine specific histone methylation and deacetylation and DNA hypermethylation are involved in the epigenetic silencing of tumor suppressor genes (TSG), e.g., p15 and p16. DNA methyltransferase (DNMT) inhibitors 5-azacytidine and 5-aza-2’-deoxycytidine demethylate the CpG dinucleotide islands in or near gene promoters, leading to derepression of TSGs in AML. SGI-110 (S110) (
Disclosures: Atadja:Novartis Institute for Biomedical Research, Inc.: Employment. Hwang:SuperGen, Inc.: Employment. Redkar:SuperGen, Inc.: Employment. Bhalla:Novartis Institute for Biomedical Research, Inc.: Honoraria, Research Funding; Merck: Research Funding.