Treatment of patients with relapsed or refractory low-grade follicular B-NHL lymphoma with rituximab has resulted in ~50% response rate. The mechanism underlying the failure of rituximab to affect the remaining 50% of the patients is not clear, though their tumors express CD20. The in vivo effector functions of rituximab include ADCC, CDC, and seldom apoptosis. In addition, we have reported that rituximab signals the cells and inhibits several intracellular cell survival pathways that are responsible for the immune and chemo-sensitizing effects of rituximab on resistant B-NHL cell lines (see review
Disclosures: No relevant conflicts of interest to declare.