Globally over 200,000 persons are afflicted with hemophilia. Topical treatments for perioperative intervention of hemophiliac bleeding are currently limited to fibrin glues, which have been used successfully to carry out dental extractions, orthopedic and non-orthopedic surgeries, and for circumcisions. Drawbacks of fibrin glues include risk of blood borne pathogen contamination and immunologic cross-reaction to factors II and V. Although topical hemostatic agents are available for treating traumatic bleeding in the field by military and EMS first responders, their effectiveness for treating bleeding in hemophilia, platelet disorders, surgery; and for other hemostatic defects observed in cirrhosis and other liver diseases and during anticoagulation therapy overdose, have not been studied. A new granular smectite hemostatic agent (WoundStat™ [WS]) has demonstrated 100% efficacy in producing hemostasis during high pressure traumatic arterial bleeding (
Disclosures: Bowlin:TraumaCure: Consultancy, Research Funding. Moskowitz:TraumaCure: Employment, Equity Ownership.