Abstract
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), a CD4+ mature lymphoproliferation that is preceded by the persistent clonal expansion of CD4+ and CD8+ infected lymphocytes. It depends on the expression of the viral oncogene tax that is restricted to the preleukemic phase of the infection. The virus prevents cell death in CD8+ lymphocytes whereas recruiting CD4+ lymphocytes into the cell cycle (
J Clin Invest.
2006
;116
:974
–983Genes to Cells
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–191Blood
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;107
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–4499Blood
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;107
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–3939J Virol.
2005
;79
:1367
–1378Disclosures: No relevant conflicts of interest to declare.
Author notes
Corresponding author
2008, The American Society of Hematology
2008