Abstract
Factor XIa (FXIa), a plasma serine protease that activates FIX, is regulated by protease nexin 2 (PN2), a Kunitz-type protease inhibitor (KPI) secreted on platelet activation. The Kunitz protease inhibitor domain of protease nexin 2 (PN2KPI) is highly homologous (45% primary sequence identity) to basic pancreatic trypsin inhibitor (BPTI, another Kunitz-type protease inhibitor) and their backbone tertiary structures are nearly identical (
J Biol Chem
280
: 36165
, 2005
J Mol Biol
230
: 919
, 2005
Disclosures: No relevant conflicts of interest to declare.
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2008, The American Society of Hematology
2008