Abstract
Mnk kinases (mitogen-activated protein kinase [MAPK]-interacting kinases) are downstream effectors of Map kinase pathways, including the MEK/Erk and the p38 Map kinase signaling cascades. We have previously shown that Mnk kinases and the p38 Map kinase pathway are activated in a negative feedback regulatory manner during treatment of cells with arsenic trioxide, and that molecular or pharmacological inhibition of their activation enhances arsenic trioxide-dependent apoptosis and antileukemic responses (
J Biol Chem
. 283
:12034
–42, 2008Cancer Res
. 66
:6763
–71, 2006
Disclosures: No relevant conflicts of interest to declare.
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2008, The American Society of Hematology
2008