Treatment Related Mortality (TRM) due to BMT conditioning regimen-related toxicity (RRT) has decreased over the past decade, but still has a major impact on patient outcome. In addition, morbidity due to non-fatal toxicity has a major impact on increased length of stay, cost and treating toxicity, while decreasing acute quality-of-life. Several reports have associated individual polymorphisms and survival, TRM, hepatic toxicity and stomatitis. We hypothesized that genetic variability affecting metabolic and detoxifying enzyme activity might explain RRT inter-individual variability. The glutathione-S-transferase (GST) isoenzymes respond to oxidative stress by detoxifying the reactive oxygen species produced by many chemotherapeutic drugs and radiation therapy. We updated our previous single center report (
Disclosure:Research Funding: This work was funded by the American Cancer Society, MSRG # 05-198-01-CCE and by the Roswell Park Alliance Foundation.