The KCl Cotransporter (KCC) is a key component of the volume regulation system of human reticulocytes, and its excessive activity in sickle cells contributes to cellular dehydration and therefore to sickling pathology. Three of the four KCC genes, are expressed in erythroid cells (
Disclosure:Consultancy: Clinton H. Joiner, Novartis Pharmaceuticals; Clinton H. Joiner, Icagen. Paid Export Testimony Information: Clinton H. Joiner. Membership Information: Clinton H. Joiner, McNeil Pharmaceuticals.