(1) In a large series of individuals alkaline phosphatase activity in the leukocyte was studied by biochemical and histochemical methods.

(2) The value of combined histochemical and biochemical measurements is demonstrated in this report.

(3) In chronic myelogenous leukemia the neutrophil contain very little alkaline phosphatase activity while in myeloid metaplasia and pyogenic infections morphologically similar cells exhibit a great increase in this enzyme.

(4) Various factors which might influence alkaline phosphatase activity in

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leukocytes were investigated and it was found that on incubation in serum or saline the cell alkaline phosphatase activity increased. However, this in vitro rise was unrelated to the source of the serum menstrum.

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