The anti-A and anti-B titers in group O individuals may vary independently following injection of group-specific substances, although such independent variation was not always seen. The rise in anti-B which followed the injection of A sub stance in some instances may have been due to traces of B activity in the A substance or to nonspecific stimulation of antibody which may follow the injection of any antigen. The part played by such factors was not determined.

It is concluded that the presence of A and B agglutinins in O individuals is not dependent on a single cellular characteristic responsible for the simultaneous formation of the isoagglutinins.

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