Sensitivity reactions to the parenteral administration of liver extract are not uncommon. They were present in 68 of 396 patients (17 per cent) receiving liver therapy.

The symptoms of sensitivity to liver extract are those of any foreign protein reaction.

Various technics can be used to circumvent reactions and still maintain patients on adequate doses of liver extract.

These methods are:

A. Changing the "brand" or type of liver extract.

B. Reducing the dose of liver extract.

C. Desensitization with liver extract.

D. Utilizing a histamine-protein complex as an antigen to produce histamine antibodies.

The latter method was successful in 10 of 11 cases in which other methods had been without effect.

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