Two cases of Still-Chauffard-Felty syndrome treated by splenectomy are presented. One case has survived five years with complete hematologic restitution and definite improvement in the arthritis. The second case expired six weeks after splenectomy. Autopsy revealed portal vein thrombosis (pylephlebitis). Both cases exhibited the blood manifestations associated with "hypersplenism." In both cases splenectomy resulted in a return of the peripheral blood picture to relative normality.