Castration has long been recognized to stimulate thymic growth and augment cellular immunity. We sought to determine whether castration affects B lymphopoiesis by analyzing the phenotype of bone marrow and spleen cells from animals postcastration. In this report, we show that the bone marrow cells from castrated male mice show a sustained, twofold to threefold increase in numbers of B220+/IgM- cells and of newly formed B220+/IgM+ B cells. Most of the expanded B220+/IgM- cell population consisted of small, HSAhi, CD43- cells characteristic of pre- B cells. The castrated animals also showed increased numbers of splenic B cells, primarily consisting of small IgM+, IgDlo, B220lo, HSAhi cells. Taken together, these results show that castration causes dramatic, long-lived enhancement of B lymphopoiesis in bone marrow and increased numbers of mature B cells in the periphery.
ARTICLES| March 15, 1995
Enhanced production of B lymphocytes after castration
Blood (1995) 85 (6): 1535–1539.
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CA Wilson, SA Mrose, DW Thomas; Enhanced production of B lymphocytes after castration. Blood 1995; 85 (6): 1535–1539. doi: https://doi.org/10.1182/blood.V85.6.1535.bloodjournal8561535
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