A group of patients is described in whom ease of fatigue, fever, splenomegaly, low blood pressure, low blood sugar, low specific gravity of the urine and the presence of infectious mononucleosis cells in the blood persisted for from three months to longer than four years after the initial attack.

Three of the group developed characteristics of lymphoblastoma and two showed the features of Banti’s congestive splenomegaly.

The symptoms responded to treatment with a preparation of adrenal cortical extract.

The syndrome is apparently not uncommon and the intense, prolonged debility, together with the marked improvement after therapy with adrenal cortical extract, makes its recognition of great practical importance.

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