A patient with chronic myeloid leukemia in whom a clinical and hematologic remission of nearly 7 years duration occurred after a single short course of busulfan is described. The only abnormal finding during the remission was a negative alkaline phosphatase reaction in her leukocytes. Chromosomal studies prior to relapse revealed a normal karyotype, and no Philadelphia chromosome was found. During relapse renewed chromosomal study revealed Philadelphia chromosome in metaphases of peripheral blood leukocytes.

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