A patient is described with addisonian pernicious anemia and with the Pelger-Huët anomaly of leukocytes. Before the patient was treated with vitamin B12, her peripheral blood contained three- and four-lobed neutrophils, but with therapy almost all the neutrophils showed the characteristic bilobed form of the Pelger-Huët anomaly. Before treatment the sex chromatin appendage was present in the neutrophils in normal numbers, but these could not be identified after treatment.

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