A critical review of the literature on the leukocytes of the guinea pig has been presented, with added observations from studies of the blood cells of more than 500 guinea pigs.

Special studies of the Kurloff inclusion body were made on these animals to obtain information regarding its origin and significance because this entity occurs in the mononuclear leukocyte, which is a cell of great interest in the pathogenesis of tuberculosis.

The normal blood picture of the guinea pig was discussed and summarized in terms of the blood picture of the normal human being.

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