Autohemolysis occurs in vitro in the blood of some patients with leukemia and other disseminated neoplastic diseases. It is known that patients with such diseases are frequently anemic and hemolytic disease frequently contributes to the anemia. The present study has demonstrated that the in vitro autohemolytic phenomenon is not necessarily associated with a short red cell life span. This suggests that the abnormality does not damage the red cells while they are in the circulation.

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