1. An abnormal cell of probably reticuloendothelial origin with prominent cytoplasmic granules was observed in the bone marrow, liver and a lymph node of an adult white female with incidentally discovered, asymptomatic hepatosplenomegaly.
2. Histochemical studies revealed the granules to consist of a chemical complex which contained bound lipid and protein.
3. The cells differed from those of Gaucher’s disease, Niemann-Pick’s disease and other storage diseases. The significance of these cells remains unknown.