Hemocompatibility and biophysical interface of left ventricular assist devices and total artificial hearts

2.

Shah

P

,

Yuzefpolskaya

M

,

Hickey

GW

, et al.

Twelfth Interagency Registry for Mechanically Assisted Circulatory Support report: readmissions after left ventricular assist device

.

Ann Thorac Surg

.

2022

;

113

(

3

):

722

-

737

.

3.

Cooley

DA

,

Liotta

D

,

Hallman

GL

,

Bloodwell

RD

,

Leachman

RD

,

Milam

JD

.

Orthotopic cardiac prosthesis for two-staged cardiac replacement

.

Am J Cardiol

.

1969

;

24

(

5

):

723

-

730

.

4.

Henn

MC

,

Mokadam

NA

.

Total artificial heart as a bridge to transplantation

.

Curr Opin Organ Transplant

.

2022

;

27

(

3

):

222

-

228

.

5.

David

C-H

,

Lacoste

P

,

Nanjaiah

P

, et al.

A heart transplant after total artificial heart support: initial and long-term results

.

Eur J Cardio Thorac Surg

.

2020

;

58

(

6

):

1175

-

1181

.

6.

Copeland

JG

,

Copeland

H

,

Gustafson

M

, et al.

Experience with more than 100 total artificial heart implants

.

J Thorac Cardiovasc Surg

.

2012

;

143

(

3

):

727

-

734

.

7.

Richez

U

,

De Castilla

H

,

Guerin

CL

, et al.

Hemocompatibility and safety of the Carmat Total Artifical Heart hybrid membrane

.

Heliyon

.

2019

;

5

(

12

):

e02914

.

8.

Bachmann

C

,

Hugo

G

,

Rosenberg

G

,

Deutsch

S

,

Fontaine

A

,

Tarbell

JM

.

Fluid dynamics of a pediatric ventricular assist device

.

Artif Organs

.

2000

;

24

(

5

):

362

-

372

.

9.

Cooper

BT

,

Roszelle

BN

,

Long

TC

,

Deutsch

S

,

Manning

KB

.

The influence of operational protocol on the fluid dynamics in the 12 cc Penn state pulsatile pediatric ventricular assist device: the effect of end-diastolic delay

.

Artif Organs

.

2010

;

34

(

4

):

E122

-

133

.

10.

Medvitz

RB

,

Reddy

V

,

Deutsch

S

,

Manning

KB

,

Paterson

EG

.

Validation of a CFD methodology for positive displacement LVAD analysis using PIV data

.

J Biomech Eng

.

2009

;

131

(

11

):

111009

.

11.

Yap

CH

,

Saikrishnan

N

,

Yoganathan

AP

.

Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet

.

Biomech Model Mechanobiol

.

2012

;

11

(

1-2

):

231

-

244

.

12.

Kroll

MH

,

Hellums

JD

,

McIntire

LV

,

Schafer

AI

,

Moake

JL

.

Platelets and shear stress

.

Blood

.

1996

;

88

(

5

):

1525

-

1541

.

13.

Panteleev

MA

,

Korin

N

,

Reesink

KD

, et al.

Wall shear rates in human and mouse arteries: standardization of hemodynamics for in vitro blood flow assays: communication from the ISTH SSC Subcommittee on biorheology

.

J Thromb Haemost

.

2021

;

19

(

2

):

588

-

595

.

14.

Song

X

,

Throckmorton

AL

,

Untaroiu

A

, et al.

Axial flow blood pumps

.

ASAIO J

.

2003

;

49

(

4

):

355

-

364

.

15.

Thamsen

B

,

Blümel

B

,

Schaller

J

, et al.

Numerical analysis of blood damage potential of the HeartMate II and HeartWare HVAD rotary blood pumps

.

Artif Organs

.

2015

;

39

(

8

):

651

-

659

.

16.

Bourque

K

,

Cotter

C

,

Dague

C

, et al.

Design rationale and preclinical evaluation of the HeartMate 3 left ventricular assist system for hemocompatibility

.

ASAIO J

.

2016

;

62

(

4

):

375

-

383

.

17.

Nascimbene

A

,

Neelamegham

S

,

Frazier

OH

,

Moake

JL

,

Dong

J-F

.

Acquired von Willebrand syndrome associated with left ventricular assist device

.

Blood

.

2016

;

127

(

25

):

3133

-

3141

.

18.

Wu

W-T

,

Yang

F

,

Wu

J

,

Aubry

N

,

Massoudi

M

,

Antaki

JF

.

High fidelity computational simulation of thrombus formation in Thoratec HeartMate II continuous flow ventricular assist device

.

Sci Rep

.

2016

;

6

:

38025

.

19.

Fraser

KH

,

Taskin

ME

,

Griffith

BP

,

Wu

ZJ

.

The use of computational fluid dynamics in the development of ventricular assist devices

.

Med Eng Phys

.

2011

;

33

(

3

):

263

-

280

.

20.

Zhang

J

,

Chen

Z

,

Griffith

BP

,

Wu

ZJ

.

Computational characterization of flow and blood damage potential of the new maglev CH-VAD pump versus the HVAD and HeartMate II pumps

.

Int J Artif Organs

.

2020

;

43

(

10

):

653

-

662

.

21.

Wiegmann

L

,

Thamsen

B

,

de Zélicourt

D

, et al.

Fluid dynamics in the HeartMate 3: influence of the artificial pulse feature and residual cardiac pulsation

.

Artif Organs

.

2019

;

43

(

4

):

363

-

376

.

22.

Boraschi

A

,

Bozzi

S

,

Thamsen

B

, et al.

Thrombotic risk of rotor speed modulation regimes of contemporary centrifugal continuous-flow left ventricular assist devices

.

ASAIO J

.

2021

;

67

(

7

):

737

-

745

.

23.

Wiegmann

L

,

Boës

S

,

de Zélicourt

D

, et al.

Blood pump design variations and their influence on hydraulic performance and indicators of hemocompatibility

.

Ann Biomed Eng

.

2018

;

46

(

3

):

417

-

428

.

24.

Mizunuma

H

,

Nakajima

R

.

Experimental study on shear stress distributions in a centrifugal blood pump

.

Artif Organs

.

2007

;

31

(

7

):

550

-

559

.

25.

Bark

DL

,

Ku

DN

.

Wall shear over high degree stenoses pertinent to atherothrombosis

.

J Biomech

.

2010

;

43

(

15

):

2970

-

2977

.

26.

Luraghi

G

,

Wu

W

,

De Castilla

H

, et al.

Numerical approach to study the behavior of an artificial ventricle: fluid-structure interaction followed by fluid dynamics with moving boundaries

.

Artif Organs

.

2018

;

42

(

10

):

E315

-

E324

.

27.

Bizouarn

P

,

Roussel

J-C

,

Trochu

J-N

,

Perlès

JC

,

Latrémouille

C

.

Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period

.

J Heart Lung Transplant

.

2018

;

37

(

1

):

161

-

163

.

28.

Netuka

I

,

Pya

Y

,

Poitier

B

, et al.

First clinical experience with the pressure sensor-based autoregulation of blood flow in an artificial heart

.

ASAIO J

.

2021

;

67

(

10

):

1100

-

1108

.

29.

Kirklin

JK

,

Naftel

DC

,

Pagani

FD

, et al.

Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation?

.

J Thorac Cardiovasc Surg

.

2012

;

144

(

3

):

584

-

603

. discussion 597-598.

30.

Starling

RC

,

Naka

Y

,

Boyle

AJ

, et al.

Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)

.

J Am Coll Cardiol

.

2011

;

57

(

19

):

1890

-

1898

.

31.

Slaughter

MS

,

Rogers

JG

,

Milano

CA

, et al.

Advanced heart failure treated with continuous-flow left ventricular assist device

.

N Engl J Med

.

2009

;

361

(

23

):

2241

-

2251

.

32.

Miller

LW

,

Pagani

FD

,

Russell

SD

, et al.

Use of a continuous-flow device in patients awaiting heart transplantation

.

N Engl J Med

.

2007

;

357

(

9

):

885

-

896

.

33.

Park

SJ

,

Milano

CA

,

Tatooles

AJ

, et al.

Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy

.

Circ Heart Fail

.

2012

;

5

(

2

):

241

-

248

.

34.

Starling

RC

,

Moazami

N

,

Silvestry

SC

, et al.

Unexpected abrupt increase in left ventricular assist device thrombosis

.

N Engl J Med

.

2014

;

370

(

1

):

33

-

40

.

35.

Kirklin

JK

,

Naftel

DC

,

Kormos

RL

, et al.

Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device

.

J Heart Lung Transplant

.

2014

;

33

(

1

):

12

-

22

.

36.

Grinstein

J

,

Belkin

MN

,

Kalantari

S

,

Bourque

K

,

Salerno

C

,

Pinney

S

.

Adverse hemodynamic consequences of continuous left ventricular mechanical support: JACC review topic of the week

.

J Am Coll Cardiol

.

2023

;

82

(

1

):

70

-

81

.

37.

Mehra

MR

,

Goldstein

DJ

,

Uriel

N

, et al.

Two-year outcomes with a magnetically levitated cardiac pump in heart failure

.

N Engl J Med

.

2018

;

378

(

15

):

1386

-

1395

.

38.

Dang

G

,

Epperla

N

,

Muppidi

V

, et al.

Medical management of pump-related thrombosis in patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis

.

ASAIO J

.

2017

;

63

(

4

):

373

-

385

.

39.

Seese

L

,

Hickey

G

,

Keebler

M

,

Thoma

F

,

Kilic

A

.

Limited efficacy of thrombolytics for pump thrombosis in durable left ventricular assist devices

.

Ann Thorac Surg

.

2020

;

110

(

6

):

2047

-

2054

.

40.

Baumann Kreuziger

L

,

Slaughter

MS

,

Sundareswaran

K

,

Mast

AE

.

Clinical relevance of histopathologic analysis of HeartMate II thrombi

.

ASAIO J

.

2018

;

64

(

6

):

754

-

759

.

41.

Da

Q

,

Teruya

M

,

Guchhait

P

,

Teruya

J

,

Olson

JS

,

Cruz

MA

.

Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices

.

Blood

.

2015

;

126

(

20

):

2338

-

2341

.

42.

Roberts

N

,

Chandrasekaran

U

,

Das

S

,

Qi

Z

,

Corbett

S

.

Hemolysis associated with Impella heart pump positioning: in vitro hemolysis testing and computational fluid dynamics modeling

.

Int J Artif Organs

.

2020

:

391398820909843

.

43.

Arora

D

,

Behr

M

,

Pasquali

M

.

Hemolysis estimation in a centrifugal blood pump using a tensor-based measure

.

Artif Organs

.

2006

;

30

(

7

):

539

-

547

.

44.

Arora

D

,

Behr

M

,

Pasquali

M

.

A tensor-based measure for estimating blood damage

.

Artif Organs

.

2004

;

28

(

11

):

1002

-

1015

.

45.

Hellums

JD

.

1993 Whitaker Lecture: biorheology in thrombosis research

.

Ann Biomed Eng

.

1994

;

22

(

5

):

445

-

455

.

46.

Carpentier

A

,

Latrémouille

C

,

Cholley

B

, et al.

First clinical use of a bioprosthetic total artificial heart: report of two cases

.

Lancet

.

2015

;

386

(

10003

):

1556

-

1563

.

47.

Poitier

B

,

Chocron

R

,

Peronino

C

, et al.

Bioprosthetic total artificial heart in autoregulated mode is biologically hemocompatible: insights for multimers of von Willebrand factor

.

Arterioscler Thromb Vasc Biol

.

2022

;

42

(

4

):

470

-

480

.

48.

Kaya

E

,

Kocabas

U

,

Simsek

E

, et al.

Effects of continuous-flow left ventricular assist device therapy on peripheral vascular function

.

ASAIO J

.

2022

;

68

(

2

):

214

-

219

.

49.

Cortese

F

,

Ciccone

MM

,

Gesualdo

M

, et al.

Continuous flow left ventricular assist devices do not worsen endothelial function in subjects with chronic heart failure: a pilot study

.

ESC Heart Fail

.

2021

;

8

(

5

):

3587

-

3593

.

50.

Watanabe

A

,

Amiya

E

,

Hatano

M

, et al.

Significant impact of left ventricular assist device models on the value of flow-mediated dilation: effects of LVAD on endothelial function

.

Heart Vessels

.

2020

;

35

(

2

):

207

-

213

.

51.

Sansone

R

,

Stanske

B

,

Keymel

S

, et al.

Macrovascular and microvascular function after implantation of left ventricular assist devices in end-stage heart failure: role of microparticles

.

J Heart Lung Transplant

.

2015

;

34

(

7

):

921

-

932

.

52.

Ivak

P

,

Netuka

I

,

Tucanova

Z

, et al.

The effect of artificial pulsatility on the peripheral vasculature in patients with continuous-flow ventricular assist devices

.

Can J Cardiol

.

2021

;

37

(

10

):

1578

-

1585

.

53.

Dlouha

D

,

Ivak

P

,

Netuka

I

, et al.

The effect of long-term left ventricular assist device support on flow-sensitive plasma microRNA levels

.

Int J Cardiol

.

2021

;

339

:

138

-

143

.

54.

Sun

H-X

,

Zeng

D-Y

,

Li

R-T

, et al.

Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase

.

Hypertension

.

2012

;

60

(

6

):

1407

-

1414

.

55.

Harris

TA

,

Yamakuchi

M

,

Ferlito

M

,

Mendell

JT

,

Lowenstein

CJ

.

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

.

Proc Natl Acad Sci U S A

.

2008

;

105

(

5

):

1516

-

1521

.

56.

Cerutti

C

,

Edwards

LJ

,

de Vries

HE

,

Sharrack

B

,

Male

DK

,

Romero

IA

.

MiR-126 and miR-126∗ regulate shear-resistant firm leukocyte adhesion to human brain endothelium

.

Sci Rep

.

2017

;

7

:

45284

.

57.

Afonyushkin

T

,

Oskolkova

OV

,

Bochkov

VN

.

Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids

.

Atherosclerosis

.

2012

;

225

(

1

):

50

-

55

.

58.

Sun

J

,

Ge

Y

,

Chao

T

,

Bai

R

,

Wang

C

.

The role of miRNA in the regulation of angiogenesis in ischemic heart disease

.

Curr Probl Cardiol

.

2023

;

48

(

6

):

101637

.

59.

Hoefer

IE

,

den Adel

B

,

Daemen

MJAP

.

Biomechanical factors as triggers of vascular growth

.

Cardiovasc Res

.

2013

;

99

(

2

):

276

-

283

.

60.

Adams

JA

,

Uryash

A

,

Lopez

JR

.

Non-invasive pulsatile shear stress modifies endothelial activation; a narrative review

.

Biomedicines

.

2022

;

10

(

12

):

3050

.

61.

Smadja

DM

,

Chocron

R

,

Rossi

E

, et al.

Autoregulation of pulsatile bioprosthetic total artificial heart is involved in endothelial homeostasis preservation

.

Thromb Haemost

.

2020

;

120

(

9

):

1313

-

1322

.

62.

Vincent

F

,

Rauch

A

,

Loobuyck

V

, et al.

Arterial pulsatility and circulating von Willebrand factor in patients on mechanical circulatory support

.

J Am Coll Cardiol

.

2018

;

71

(

19

):

2106

-

2118

.

63.

Latrémouille

C

,

Duveau

D

,

Cholley

B

, et al.

Animal studies with the Carmat bioprosthetic total artificial heart

.

Eur J Cardio Thorac Surg

.

2015

;

47

(

5

):

e172

-

e178

. discussion e178-179.

64.

Smadja

DM

,

Susen

S

,

Rauch

A

, et al.

The Carmat bioprosthetic total artificial heart is associated with early hemostatic recovery and no acquired von Willebrand syndrome in calves

.

J Cardiothorac Vasc Anesth

.

2017

;

31

(

5

):

1595

-

1602

.

65.

Latrémouille

C

,

Carpentier

A

,

Leprince

P

, et al.

A bioprosthetic total artificial heart for end-stage heart failure: results from a pilot study

.

J Heart Lung Transplant

.

2018

;

37

(

1

):

33

-

37

.

66.

Smadja

DM

,

Saubaméa

B

,

Susen

S

, et al.

Bioprosthetic total artificial heart induces a profile of acquired hemocompatibility with membranes recellularization

.

J Am Coll Cardiol

.

2017

;

70

(

3

):

404

-

406

.

67.

Guerin

CL

,

Guyonnet

L

,

Goudot

G

, et al.

Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells

.

Stem Cell Rev Rep

.

2021

;

17

(

2

):

639

-

651

.

68.

Guyonnet

L

,

Detriché

G

,

Gendron

N

, et al.

Elevated circulating stem cells level is observed one month after implantation of Carmat bioprosthetic total artificial heart

.

Stem Cell Rev Rep

.

2021

;

17

(

6

):

2332

-

2337

.

69.

Schaub

RD

,

Kameneva

MV

,

Borovetz

HS

,

Wagner

WR

.

Assessing acute platelet adhesion on opaque metallic and polymeric biomaterials with fiber optic microscopy

.

J Biomed Mater Res

.

2000

;

49

(

4

):

460

-

468

.

70.

Maas

C

,

Renné

T

.

Regulatory mechanisms of the plasma contact system

.

Thromb Res

.

2012

;

129

(

Suppl 2

):

S73

-

76

.

71.

Himmelreich

G

,

Ullmann

H

,

Riess

H

, et al.

Pathophysiologic role of contact activation in bleeding followed by thromboembolic complications after implantation of a ventricular assist device

.

ASAIO J

.

1995

;

41

(

3

):

M790

-

794

.

72.

Ankersmit

HJ

,

Tugulea

S

,

Spanier

T

, et al.

Activation-induced T-cell death and immune dysfunction after implantation of left-ventricular assist device

.

Lancet

.

1999

;

354

(

9178

):

550

-

555

.

73.

Deng

MC

,

Erren

M

,

Tjan

TD

, et al.

Left ventricular assist system support is associated with persistent inflammation and temporary immunosuppression

.

Thorac Cardiovasc Surg

.

1999

;

47

(

suppl 2

):

326

-

331

.

74.

Grosman-Rimon

L

,

McDonald

MA

,

Jacobs

I

, et al.

Markers of inflammation in recipients of continuous-flow left ventricular assist devices

.

ASAIO J

.

2014

;

60

(

6

):

657

-

663

.

75.

Masai

T

,

Sawa

Y

,

Ohtake

S

, et al.

Hepatic dysfunction after left ventricular mechanical assist in patients with end-stage heart failure: role of inflammatory response and hepatic microcirculation

.

Ann Thorac Surg

.

2002

;

73

(

2

):

549

-

555

.

76.

Caruso

R

,

Trunfio

S

,

Milazzo

F

, et al.

Early expression of pro- and anti-inflammatory cytokines in left ventricular assist device recipients with multiple organ failure syndrome

.

ASAIO J

.

2010

;

56

(

4

):

313

-

318

.

77.

Caruso

R

,

Caselli

C

,

Cozzi

L

, et al.

Myocardial interleukin-6 in the setting of left ventricular mechanical assistance: relation with outcome and C-reactive protein

.

Clin Chem Lab Med

.

2015

;

53

(

9

):

1359

-

1366

.

78.

Caruso

R

,

Verde

A

,

Campolo

J

, et al.

Severity of oxidative stress and inflammatory activation in end-stage heart failure patients are unaltered after 1 month of left ventricular mechanical assistance

.

Cytokine

.

2012

;

59

(

1

):

138

-

144

.

79.

Tabit

CE

,

Coplan

MJ

,

Chen

P

,

Jeevanandam

V

,

Uriel

N

,

Liao

JK

.

Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices

.

J Heart Lung Transplant

.

2018

;

37

(

1

):

107

-

115

.

80.

Woolley

JR

,

Teuteberg

JJ

,

Bermudez

CA

, et al.

Temporal leukocyte numbers and granulocyte activation in pulsatile and rotary ventricular assist device patients

.

Artif Organs

.

2014

;

38

(

6

):

447

-

455

.

81.

Pronschinske

KB

,

Qiu

S

,

Wu

C

, et al.

Neutrophil gelatinase-associated lipocalin and cystatin C for the prediction of clinical events in patients with advanced heart failure and after ventricular assist device placement

.

J Heart Lung Transplant

.

2014

;

33

(

12

):

1215

-

1222

.

82.

Grosman-Rimon

L

,

Hui

SG

,

Freedman

D

,

Elbaz-Greener

G

,

Cherney

D

,

Rao

V

.

Biomarkers of inflammation, fibrosis, and acute kidney injury in patients with heart failure with and without left ventricular assist device implantation

.

Cardiorenal Med

.

2019

;

9

(

2

):

108

-

116

.

83.

Carminita

E

,

Crescence

L

,

Panicot-Dubois

L

,

Dubois

C

.

Role of neutrophils and NETs in animal models of thrombosis

.

Int J Mol Sci

.

2022

;

23

(

3

):

1411

.

84.

Granja

T

,

Magunia

H

,

Schüssel

P

, et al.

Left ventricular assist device implantation causes platelet dysfunction and proinflammatory platelet-neutrophil interaction

.

Platelets

.

2022

;

33

(

1

):

132

-

140

.

85.

Hennessy-Strahs

S

,

Bermudez

CA

,

Acker

MA

,

Bartoli

CR

.

Toward a standard practice to quantify von Willebrand factor degradation during left ventricular assist device support

.

Ann Thorac Surg

.

2021

;

112

(

4

):

1257

-

1264

.

86.

Bartoli

CR

.

Pathologic von Willebrand factor degradation is a major contributor to left ventricular assist device-associated bleeding: pathophysiology and evolving clinical management

.

Ann Cardiothorac Surg

.

2021

;

10

(

3

):

389

-

392

.

87.

Crow

S

,

Milano

C

,

Joyce

L

, et al.

Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients

.

ASAIO J

.

2010

;

56

(

5

):

441

-

445

.

88.

Lahpor

J

,

Khaghani

A

,

Hetzer

R

, et al.

European results with a continuous-flow ventricular assist device for advanced heart-failure patients

.

Eur J Cardio Thorac Surg

.

2010

;

37

(

2

):

357

-

361

.

89.

Wieselthaler

GM

,

O Driscoll

G

,

Jansz

P

,

Khaghani

A

,

Strueber

M

;

HVAD Clinical Investigators

.

Initial clinical experience with a novel left ventricular assist device with a magnetically levitated rotor in a multi-institutional trial

.

J Heart Lung Transplant

.

2010

;

29

(

11

):

1218

-

1225

.

90.

Meyer

AL

,

Malehsa

D

,

Budde

U

,

Bara

C

,

Haverich

A

,

Strueber

M

.

Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device

.

JACC Heart Fail

.

2014

;

2

(

2

):

141

-

145

.

91.

Mehra

MR

,

Goldstein

DJ

,

Cleveland

JC

, et al.

Five-year outcomes in patients with fully magnetically levitated vs axial-flow left ventricular assist devices in the MOMENTUM 3 randomized trial

.

JAMA

.

2022

;

328

(

12

):

1233

-

1242

.

92.

Kataria

R

,

Jorde

UP

.

Gastrointestinal bleeding during continuous-flow left ventricular assist device support: state of the field

.

Cardiol Rev

.

2019

;

27

(

1

):

8

-

13

.

93.

Gill

JC

,

Endres-Brooks

J

,

Bauer

PJ

,

Marks

WJ

,

Montgomery

RR

.

The effect of ABO blood group on the diagnosis of von Willebrand disease

.

Blood

.

1987

;

69

(

6

):

1691

-

1695

.

94.

Tscharre

M

,

Wittmann

F

,

Kitzmantl

D

, et al.

Impact of ABO blood group on thromboembolic and bleeding complications in patients with left ventricular assist devices

.

Thromb Haemost

.

2023

;

123

(

3

):

336

-

346

.

95.

Netuka

I

,

Ivák

P

,

Tučanová

Z

, et al.

Evaluation of low-intensity anti-coagulation with a fully magnetically levitated centrifugal-flow circulatory pump-the MAGENTUM 1 study

.

J Heart Lung Transplant

.

2018

;

37

(

5

):

579

-

586

.

96.

Mehra

MR

,

Crandall

DL

,

Gustafsson

F

, et al.

Aspirin and left ventricular assist devices: rationale and design for the international randomized, placebo-controlled, non-inferiority ARIES HM3 trial

.

Eur J Heart Fail

.

2021

;

23

(

7

):

1226

-

1237

.

97.

Bartoli

CR

,

Kang

J

,

Restle

DJ

, et al.

Inhibition of ADAMTS-13 by doxycycline reduces von Willebrand factor degradation during supraphysiological shear stress: therapeutic implications for left ventricular assist device-associated bleeding

.

JACC Heart Fail

.

2015

;

3

(

11

):

860

-

869

.

98.

Imamura

T

,

Nguyen

A

,

Rodgers

D

, et al.

Omega-3 therapy is associated with reduced gastrointestinal bleeding in patients with continuous-flow left ventricular assist device

.

Circ Heart Fail

.

2018

;

11

(

10

):

e005082

.

99.

Asleh

R

,

Albitar

HAH

,

Schettle

SD

, et al.

Intravenous bevacizumab as a novel treatment for refractory left ventricular assist device-related gastrointestinal bleeding

.

J Heart Lung Transplant

.

2020

;

39

(

5

):

492

-

495

.

100.

Geisen

U

,

Heilmann

C

,

Beyersdorf

F

, et al.

Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease

.

Eur J Cardio Thorac Surg

.

2008

;

33

(

4

):

679

-

684

.

101.

Vincentelli

A

,

Susen

S

,

Le Tourneau

T

, et al.

Acquired von Willebrand syndrome in aortic stenosis

.

N Engl J Med

.

2003

;

349

(

4

):

343

-

349

.

102.

Van Belle

E

,

Rauch

A

,

Vincentelli

A

, et al.

Von Willebrand factor as a biological sensor of blood flow to monitor percutaneous aortic valve interventions

.

Circ Res

.

2015

;

116

(

7

):

1193

-

1201

.

103.

Goda

M

,

Jacobs

S

,

Rega

F

, et al.

Time course of acquired von Willebrand disease associated with two types of continuous-flow left ventricular assist devices: HeartMate II and CircuLite Synergy Pocket Micro-pump

.

J Heart Lung Transplant

.

2013

;

32

(

5

):

539

-

545

.

104.

Tsai

HM

,

Sussman

II

,

Nagel

RL

.

Shear stress enhances the proteolysis of von Willebrand factor in normal plasma

.

Blood

.

1994

;

83

(

8

):

2171

-

2179

.

105.

Dong

J

,

Moake

JL

,

Nolasco

L

, et al.

ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

.

Blood

.

2002

;

100

(

12

):

4033

-

4039

.

106.

Ikeda

Y

,

Handa

M

,

Kawano

K

, et al.

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

.

J Clin Invest

.

1991

;

87

(

4

):

1234

-

1240

.

107.

Moake

JL

,

Turner

NA

,

Stathopoulos

NA

,

Nolasco

L

,

Hellums

JD

.

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

.

Blood

.

1988

;

71

(

5

):

1366

-

1374

.

108.

Chow

TW

,

Hellums

JD

,

Moake

JL

,

Kroll

MH

.

Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation

.

Blood

.

1992

;

80

(

1

):

113

-

120

.

109.

Bartoli

CR

,

Zhang

D

,

Kang

J

, et al.

Clinical and in vitro evidence that subclinical hemolysis contributes to LVAD thrombosis

.

Ann Thorac Surg

.

2018

;

105

(

3

):

807

-

814

.

110.

Zhang

J

,

Bergeron

AL

,

Yu

Q

, et al.

Platelet aggregation and activation under complex patterns of shear stress

.

Thromb Haemost

.

2002

;

88

(

5

):

817

-

821

.

111.

Zhang

J

,

Bergeron

AL

,

Yu

Q

, et al.

Duration of exposure to high fluid shear stress is critical in shear-induced platelet activation-aggregation

.

Thromb Haemost

.

2003

;

90

(

4

):

672

-

678

.

112.

Tripodi

A

,

Chantarangkul

V

,

Böhm

M

, et al.

Measurement of von Willebrand factor cleaving protease (ADAMTS-13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas

.

J Thromb Haemost

.

2004

;

2

(

9

):

1601

-

1609

.

113.

Kokame

K

,

Nobe

Y

,

Kokubo

Y

,

Okayama

A

,

Miyata

T

.

FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay

.

Br J Haematol

.

2005

;

129

(

1

):

93

-

100

.

114.

Nascimbene

A

,

Hilton

T

,

Konkle

BA

,

Moake

JL

,

Frazier

OH

,

Dong

JF

.

von Willebrand factor proteolysis by ADAMTS-13 in patients on left ventricular assist device support

.

J Heart Lung Transplant

.

2017

;

36

(

4

):

477

-

479

.

115.

Fu

X

,

Chen

J

,

Gallagher

R

,

Zheng

Y

,

Chung

DW

,

López

JA

.

Shear stress-induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region

.

Blood

.

2011

;

118

(

19

):

5283

-

5291

.

116.

Mondal

NK

,

Sorensen

EN

,

Pham

SM

, et al.

Systemic inflammatory response syndrome in end-stage heart failure patients following continuous-flow left ventricular assist device implantation: differences in plasma redox status and leukocyte activation

.

Artif Organs

.

2016

;

40

(

5

):

434

-

443

.

117.

Mondal

NK

,

Chen

Z

,

Trivedi

JR

, et al.

Association of oxidative stress and platelet receptor glycoprotein GPIbα and GPVI shedding during nonsurgical bleeding in heart failure patients with continuous-flow left ventricular assist device support

.

ASAIO J

.

2018

;

64

(

4

):

462

-

471

.

118.

Chen

J

,

Fu

X

,

Wang

Y

, et al.

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

.

Blood

.

2010

;

115

(

3

):

706

-

712

.

119.

Wang

Y

,

Chen

J

,

Ling

M

,

López

JA

,

Chung

DW

,

Fu

X

.

Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation

.

J Biol Chem

.

2015

;

290

(

3

):

1422

-

1431

.

120.

Zhou

Z

,

Han

H

,

Cruz

MA

,

López

JA

,

Dong

JF

,

Guchhait

P

.

Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease

.

Thromb Haemost

.

2009

;

101

(

6

):

1070

-

1077

.

121.

Martin

C

,

Morales

LD

,

Cruz

MA

.

Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha

.

J Thromb Haemost

.

2007

;

5

(

7

):

1363

-

1370

.

122.

Ju

L

.

Dynamic force spectroscopy analysis on the Redox states of protein disulphide bonds

.

Methods Mol Biol

.

2019

;

1967

:

115

-

131

.

123.

Yang

M

,

Houck

KL

,

Dong

X

, et al.

Hyperadhesive von Willebrand factor promotes extracellular vesicle-induced angiogenesis: implication for LVAD-induced bleeding

.

JACC Basic Transl Sci

.

2022

;

7

(

3

):

247

-

261

.

124.

Suarez

J

,

Patel

CB

,

Felker

GM

,

Becker

R

,

Hernandez

AF

,

Rogers

JG

.

Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices

.

Circ Heart Fail

.

2011

;

4

(

6

):

779

-

784

.

125.

Zhou

Y

,

Qin

S

,

Hilton

T

, et al.

Quantification of von Willebrand factor cleavage by adamts-13 in patients supported by left ventricular assist devices

.

ASAIO J

.

2017

;

63

(

6

):

849

-

853

.

126.

Heilmann

C

,

Geisen

U

,

Beyersdorf

F

, et al.

Acquired von Willebrand syndrome in patients with ventricular assist device or total artificial heart

.

Thromb Haemost

.

2010

;

103

(

5

):

962

-

967

.

127.

Reich

HJ

,

Morgan

J

,

Arabia

F

, et al.

Comparative analysis of von Willebrand factor profiles after implantation of left ventricular assist device and total artificial heart

.

J Thromb Haemost

.

2017

;

15

(

8

):

1620

-

1624

.

128.

Oezpeker

C

,

Zittermann

A

,

Baurichter

D

, et al.

Changes in von Willebrand factor profile predicts clinical outcomes in patients on mechanical circulatory support

.

J Card Surg

.

2018

;

33

(

10

):

693

-

702

.

129.

Rauch

A

,

Legendre

P

,

Christophe

OD

, et al.

Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices

.

Thromb Haemost

.

2014

;

112

(

5

):

1014

-

1023

.

130.

Connors

JM

,

Gregor

S

,

Crandall

D

,

Netuka

I

,

Mehra

MR

.

Low-intensity anti-coagulation using Vitamin K antagonists and factor X activity: a validation analysis of the MAGENTUM-1 study

.

J Heart Lung Transplant

.

2019

;

38

(

6

):

668

-

669

.

131.

Copeland

JG

.

SynCardia Total Artificial Heart: update and future

.

Tex Heart Inst J

.

2013

;

40

(

5

):

587

-

588

.

132.

Smadja

DM

,

Ivak

P

,

Pya

Y

, et al.

Intermediate-dose prophylactic anticoagulation with low molecular weight heparin is safe after bioprosthetic artificial heart implantation

.

J Heart Lung Transplant

.

2022

;

41

(

9

):

1214

-

1217

.

133.

Cho

S-M

,

Moazami

N

,

Katz

S

,

Starling

R

,

Frontera

JA

.

Reversal and resumption of antithrombotic therapy in LVAD-associated intracranial hemorrhage

.

Ann Thorac Surg

.

2019

;

108

(

1

):

52

-

58

.

134.

Loyaga-Rendon

RY

,

Kazui

T

,

Acharya

D

.

Antiplatelet and anticoagulation strategies for left ventricular assist devices

.

Ann Transl Med

.

2021

;

9

(

6

):

521

.

135.

Kormos

RL

,

Cowger

J

,

Pagani

FD

, et al.

The Society of Thoracic Surgeons Intermacs database annual report: evolving indications, outcomes, and scientific partnerships

.

J Heart Lung Transplant

.

2019

;

38

(

2

):

114

-

126

.

136.

Kassi

M

,

Agrawal

T

,

Xu

J

, et al.

Outflow cannula alignment in continuous flow left ventricular devices is associated with stroke

.

Int J Artif Organs

.

2023

;

46

(

4

):

226

-

234

.

137.

Bishawi

M

,

Joseph

J

,

Patel

C

, et al.

Risk factors for stroke on left ventricular assist devices

.

J Card Surg

.

2018

;

33

(

6

):

348

-

352

.

138.

Pullicino

PM

,

Halperin

JL

,

Thompson

JL

.

Stroke in patients with heart failure and reduced left ventricular ejection fraction

.

Neurology

.

2000

;

54

(

2

):

288

-

294

.

139.

Aggarwal

A

,

Gupta

A

,

Kumar

S

, et al.

Are blood stream infections associated with an increased risk of hemorrhagic stroke in patients with a left ventricular assist device?

.

ASAIO J

.

2012

;

58

(

5

):

509

-

513

.

140.

Menon

AK

,

Götzenich

A

,

Sassmannshausen

H

,

Haushofer

M

,

Autschbach

R

,

Spillner

JW

.

Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation

.

Eur J Cardio Thorac Surg

.

2012

;

42

(

2

):

319

-

323

. discussion 323.

141.

Najjar

SS

,

Slaughter

MS

,

Pagani

FD

, et al.

An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial

.

J Heart Lung Transplant

.

2014

;

33

(

1

):

23

-

34

.