TO THE EDITOR:

Rearrangements in cytokine receptor–like factor 2 (CRLF2r) represent a subset of B-cell acute lymphoblastic leukemia (B-ALL) that demonstrates poorer survival in children and adults.1,2  An increased incidence of acute lymphoblastic leukemia (ALL) with CRLF2r has been consistently reported in patients of Latinx ethnicity,1-3  likely contributing to poorer outcomes. Separately, Hispanic/Latinx populations exhibit high rates of obesity, a host factor independently associated with the risk for developing B-ALL5,6  and poorer survival.7,8  Obesity may promote leukemogenesis and impair disease response via multiple mechanisms, including hormones, adipokines, and direct interactions with adipocytes9-14 ; however, no studies to our knowledge have examined whether obese patients are at a higher risk of developing any specific genomic subtype of ALL. Indeed, despite the higher rates of obesity in the Hispanic/Latinx population, and the connection of...

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