TO THE EDITOR:

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cutaneous T-cell lymphoma characterized by a hypodermal infiltration of CD8 T cells expressing an αβ T-cell receptor. Since 2005, SPTCL has been considered a distinct entity from ɣδ T-cell lymphoma in the World Health Organization/European Organization for Research and Treatment of Cancer (EORTC) classification. An EORTC study of 63 cases showed the excellent prognosis of SPTCL without associated hemophagocytic syndrome (HPS) and questioned the use of polychemotherapy as first-line treatment. These results were further supported by 2 recent studies.2,3  However, a minority of patients develops aggressive disease, the determinants of which are not understood. The presence of HPS accompanying SPTCL is associated with shorter overall survival. A recent study has identified germline homozygous or compound heterozygous loss-of-function Hepatitis A Virus-Cellular Receptor 2 (HAVCR2, encoding T-Cell Immunoglobulin...

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