TO THE EDITOR:
Waldenstrom macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma associated with immunoglobulin M monoclonal gammopathy.1 The majority of patients carry the L265P mutation in MYD88,2 whereas 40% of patients carry mutations in CXCR4.3 Mutation status has an impact on response to treatment with ibrutinib, ixazomib, and everolimus, with CXCR4-mutated WM cases demonstrating resistance to these agents.4-6
Bortezomib, a proteasome inhibitor that is the mainstay of treatment of multiple myeloma, is also effective in WM7 ; however, its relation to CXCR4 mutation status in WM has not been fully explored. In this study, we describe the impact of CXCR4 mutations on progression-free survival and overall survival of WM patients under treatment with a bortezomib-based combination and attempt to frame that in the context of pan-cancer data on CXCR4 expression and bortezomib sensitivity.
Sixty-three patients with...