Bone marrow CX3CR11 mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice

Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.

Prolonged survival with the early use of a novel extracorporeal photopheresis regimen in patientswith Sézary syndrome

Gao et al report that early use of extracorporeal photopheresis improves time to next treatment and survival in patients with Seézary syndrome.

Filamin A: key actor in platelet biology

Filamins are scaffold proteins for signaling proteins and adhesion molecules, and mutations in filamin A (FLNa) cause a wide range of defects in the brain, cardiovascular system, gastrointestinal tract, and skeleton, as well as in megakaryocytes. Rosa and colleagues review the important role of FLNa in platelet development and its critical importance to proplatelet production by megakaryocytes.

Impact of concurrent indolent lymphoma on the clinical outcome of newly diagnosed diffuse large B-cell lymphoma

• Concurrent DLBCL and FL has a similar outcome to that of GCB DLBCL; concurrent other indolent lymphoma does not worsen the DLBCL outcome.

• Inclusion of patients with concurrent DLBCL and indolent lymphoma should be considered in clinical trials of newly diagnosed DLBCL.

Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-precursor ALL (B-ALL) characterized by a gene-expression profile similar to Ph+ ALL but lacking the specific BCR-ABL1 fusion gene.1

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes

• The cyclic resveratrol trimer caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells.

• Caraphenol A decreases interferon-induced transmembrane protein-mediated restriction in an endosomal trafficking-dependent manner.