Targeting natural anticoagulant proteins as a means to rebalance the hemostatic system is an emerging trend in the development of innovative therapeutic strategies for hemophilia.
Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1N terminus in erythropoiesis
GATA1 has a foundational role in erythropoiesis. The investigators compare the function of 2 forms (the full-length protein and a shorter form) of the transcription factor GATA1 and show that the N-terminal domain of GATA1 is critical to red cell differentiation.
In this Blood Spotlight, the authors review the appropriate clinical background, mechanism of action, and detailed therapeutic data about duvelisib in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma.
Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising 3 distinct clinical subtypes: sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in the setting of HIV.
This study reveals that successful therapeutic targeting of the CD47-SIRPa axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcgR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.
These studies demonstrate how activation of the NLRP3 inflammasome pathway influences the function of myeloid-derived suppressor cells (MDSCs) in the setting of acute graft-versus-host disease (aGVHD)..