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Red Blood Cell and Iron Disorders

December 20, 2021

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Multiparameter Microfluidic Thrombus Formation Testing Helps Identify Platelet Disorders

For patients with a platelet function disorder, it is often difficult to identify the underlying genetic cause of the bleeding diathesis ...

Ruxolitinib Demonstrates Superior Benefits in PV Resistant or Intolerant to Hydroxycarbamide

Ruxolitinib treatment resulted in superior complete response (CR), event-free survival (EFS), and molecular response compared with best available therapy ...

Understanding the Correlation Between GLS and Ventricular Arrhythmia in SCA

Sudden death is a common yet unexplained cause of mortality in adults living with sickle cell anemia (SCA), accounting for about 20% of their deaths ...

Rusfertide Effectively Supports Hematocrit Control in PV

The investigational hepcidin mimetic rusfertide effectively controlled erythrocytosis in patients with polycythemia vera (PV) who were receiving therapeutic phlebotomy ...

Elevated Blood Flow Velocity Associated With Risk of Cognitive Deficits in Pediatric SCD

Cognitive deficits in children with sickle cell disease (SCD) were associated with the neuroimaging findings of higher cerebral blood flow velocity, stroke or silent cerebral infarction ...

Study Gives Definitive Look at Life Expectancy in SCD

Patients with sickle cell disease (SCD) tend to have inferior survival compared to the general population, according to the first periodic life table for SCD based on actual population ...

Combined Biomarker Panel Could Speed Diagnosis of Chronic Kidney Disease in SCD

The use of combined biomarkers targeting three main pathophysiologic mechanisms of sickle cell disease (SCD) significantly improved the accuracy of detection of early-stage chronic kidney disease ...

Hydroxyurea Adherence Linked With Better Clinical Outcomes in SCD

Only about one in five patients with sickle cell disease (SCD) enrolled in Texas Medicaid were adherent to hydroxyurea therapy ...

Study Characterizes Mutational Pattern of Non-Immune Hemolytic Anemia in MDS

Patients with myelodysplastic syndromes (MDS) and non-immune hemolysis were more likely to have EZH2 and U2AF1 mutations ...

HU May Lower Malaria Incidence in Children With Sickle Cell Anemia

In children with sickle cell anemia in Africa, the maximum tolerated dose (MTD) of hydroxyurea (HU) is associated with a lower incidence of malaria ...

 

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