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Red Blood Cell and Iron Disorders

December 20, 2021

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Hydroxyurea Adherence Linked With Better Clinical Outcomes in SCD

Only about one in five patients with sickle cell disease (SCD) enrolled in Texas Medicaid were adherent to hydroxyurea therapy ...

Study Characterizes Mutational Pattern of Non-Immune Hemolytic Anemia in MDS

Patients with myelodysplastic syndromes (MDS) and non-immune hemolysis were more likely to have EZH2 and U2AF1 mutations ...

HU May Lower Malaria Incidence in Children With Sickle Cell Anemia

In children with sickle cell anemia in Africa, the maximum tolerated dose (MTD) of hydroxyurea (HU) is associated with a lower incidence of malaria ...

Sutimlimab Produces Favorable Results in Patients With Cold Agglutinin Disease 

More than one year of treatment with sutimlimab in patients with cold agglutinin disease was associated with continued inhibition of hemolysis as well as sustained improvements in anemia and quality of life ...

Long-Term Remission Seen in Cold Agglutinin Disease After Sutimlimab Discontinuation

Treatment with sutimlimab unexpectedly led to a long-term response in two patients with cold agglutinin disease after active treatment was ended, according to findings of a post-trial observational study ...

Pharmacologic Thromboprophylaxis Increased in Adolescents With SCD Between 2010 and 2021

Patients with sickle cell disease (SCD) are at an increased risk of developing venous thromboembolism (VTE), leading to the use of pharmacologic and mechanical thromboprophylaxis ...

Review Confirms Likely Short-Term Benefits of HU in SCD

Hydroxyurea (HU) increased fetal hemoglobin and likely decreased the frequency of pain episodes and other acute complications in persons with sickle cell anemia of hemoglobin SS ...

HCT Improves Blood Dynamics, Protects Against Stroke in Children With SCD

Children with SCD have a risk of overt stroke and silent cerebral infarction SCI and generally receive chronic red blood cell transfusion therapy, which reduces the risk of having ...

IV Iron May Decrease RBC Transfusion Need in Chemotherapy-Induced Anemia

Researchers completed a meta-analysis of randomized, controlled trials that compared IV iron with either no iron or oral iron for the treatment of CIA to assess the effect of IV iron as a monotherapy ...






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